The 2019 Novel Coronavirus Resource (2019nCoVR, https://bigd.big.ac.cn/ncov) was constructed by China National Center for Bioinformation (CNCB)/National Genomics Data Center (NGDC), Beijing Institute of Genomics, Chinese Academy of Sciences. It features comprehensive integration of genomic and proteomic sequences as well as their metadata information from the Global Initiative on Sharing All Influenza Data, National Center for Biotechnology Information (NCBI), China National GeneBank, National Microbiology Data Center and CNCB/NGDC. It also incorporates a wide range of relevant information including scientific literatures, news, and popular articles for science dissemination, and provides visualization functionalities for genome variation analysis results based on all collected 2019-nCoV strains. As of March 29, 2019nCoVR has integrated 40,221 coronavirus sequences, 2,596 novel coronavirus genomes, 1,803 variants identified from human-derived novel coronaviruses and 3,343 related literatures. It provides basic metadata, virus distribution map, phylogenetic relationships of all published 2019-nCoV genomes, quality evaluation information of each genome sequence and variant site, and comprehensive analysis results of all genomic variants including basic statistics, detailed annotation and spatio-temporal frequency dynamics. Notably, genotype maps of 2019-nCoVs across the world are provided based on available high-quality genome sequences. Online tools such as ‘Variation Identification’ and ‘Variation Annotation’ are also deployed to further researches on novel coronavirus. Moreover, by linking seamlessly with related databases in CNCB/NGDC, 2019nCoVR offers virus data submission and sharing services for raw sequence reads and assembled sequences. Through a data exchange mechanism established with NCBI, data submitted to the resource are shared with international databases. For example, the first complete genome sequence of SARS-CoV-2 from Pakistan, submitted by National University of Sciences and Technology, Pakistan has been released in CNCB/NGDC (GWHACDD01000000) and NCBI (MT240479). Within two month after the release of the resource, it has served over 84,000 users from 156 countries/regions. The sequences have been downloaded more than 4.9 million times. CNCB became an Association of ANSO in 2019. We call on worldwide collaborations on data sharing and welcome any feedback for further improvement of the resource. Please contact Dr. Yiming Bao, baoym@big.ac.cn.